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A Radboud Personalized Healthcare Centre

Welcome to the Nijmegen Centre for Mitochondrial Disorders (NCMD). The NCMD is an international expert centre for clinical care, diagnostics and research for patients with or suspected of having a mitochondrial energy disorder. The NCMD integrates all mitochondrial related care, diagnostics and research within the Radboud University Medical Center. The NCMD is part of an extended international network of international research centres, patient organisations and other stakeholders across the globe. The NCMD is powered by govermental bodies and national and international foundations.

"The NCMD mission is to understand cellular bioenergetics in health and disease at all levels of complexity in order to develop preventive measures and make substantial contributions towards the development of rational treatment strategies for mitochondrial disease. As such a from molecule to man - to population - to patient, strategy has been adopted."

Prof. Dr. Jan Smeitink – Chairman of the Board

Inner membrane

The mitochondrial inner membrane is a lipid bilayer that contains various protein complexes, including the oxidative phosphorylation system.

Intermitochondrial space

The space between the mitochondrial inner and outer membranes is called the intermitochondrial space


Enveloped by the inner membrane, the mitochondrial matrix is the fluid central compartment of the mitochondrion.

Outer membrane

The mitochondrial outer membrane forms the gatekeeper between the mitochondrion and the rest of the cell.


  • The NCMD webpage now has multi-language support. Select the language of choice on the top of the page.
  • The national information day for mitochondrial diseases will be held on September 26 at the Radboudumc. More information will follow soon!


Patient care

At the NCMD clinic patient care is central. In addition to providing diagnosis, councelling, and supportive care, all activities are aimed at developing a therapy for mitochondrial disorders.



NCMD diagnostics focuses on the genetic as well as enzymatic defects causing mitochondrial disorders. If the cause remains unfound, after informed consent, further research is performed.

Go to Diagnostics





Our research covers a wide range of topics all focused on gaining a better understanding of the molecular and physiological consequences of mitochondrial disorders as well as finding entry points for therapy. 

Go to Research


I want to know more

If you would like to learn more about the NCMD or about mitochondrial disorders feel free to visit our patient portal (Dutch), to visit our archives, to order our brochure, or to submit a question below.

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Submit your question

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Order our booklet

Together with a panel of international experts, we have created a clinical guide on Mitochondrial Medicine. This illustrated booklet provides an extensive overview of mitochondrial disease, and can be ordered.

Order our booklet

Download section

Here you can find publically available general documentation and documents for professionals and press.